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Treatment with semaglutide 2.4 mg also significantly improved symptoms, evaluated with the Kansas City Cardiomiopathy Questionnaire, and physical limitations, evaluated with the 6 min walking test, in the STEP-HFpEF trial, enrolling 529 patients with obesity and HF with preserved ejection fraction 89
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The comparison between phentermine and GLP-1 medications and the phentermine versus semaglutide comparison may also be relevant for patients exploring lower-cost pharmaceutical alternatives when GLP-1 access becomes restricted
Exercise alone led to similar improvements in cardiorespiratory fitness as the combined treatment, superior to liraglutide alone (3.8 mL/min/kg FFM [95% CI 1.2, 6.4]) and placebo (6.1 mL/min/kg FFM [95% CI 3.5, 8.7])
vol 136, pp1523-1533.
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